Comparative study evaluating nocturnal ocular blood flow, BP and IOP in patients w/ OAG and control (Dr Nir Shoham)

26Jun2010 1435hrs presented at the COS Annual Meeting in Quebec City by Dr Nir Shoham

The speaker begins with an overview of blood flow risk to visual field loss and how the purpose of this study was to evaluate nocturnal blood flow, blood pressure and intraocular pressure.

The IOP was higher in the study group of treated open angle glaucoma patients on meds compared to the control group. The fluctuation of Diastolic Ocular Perfusion Pressure (OPP) was significantly lower in treated groups but higher variation in IOP in these patients.

At this point, the speaker did a lightening speed fly through of all his slides as he read a script the whole time and I could not keep up with his talk. He did talk about perfusion being shown to be important in other studies as well and discussed the belief that auto regulation of perfusion pressure as the underlying mechanism.

Really the take home message of this study is reduced nocturnal (Diastolic Ocular Perfusion Pressure) DOPP has a role in glaucoma.

Habitual IOP

Q: What position were patients when measured

A: They were upright (therefore NOT habitual, ie may have no relevance to reality as most patients are supine during the night; I have included a graph of habitual IOP to show how IOP is higher when patients are in their habitual positioning, that is lying down to sleep. In this study patients were upright for the nocturnal measurements - a flaw in applying this to the real world.)

Q: There has been a lot of variability in the way perfusion is measured….(much of question not heard as mic off most of time)